This gene encodes a nuclear protein that interacts with hepatitis B virus X protein (HBX) and facilitates transcription of hepatitis B virus genes by the HBX transcription activator, suggesting a role for this interaction in the virus life cycle. This protein also interacts with SNF2H protein to form the RSF chromatin-remodeling complex, where the SNF2H subunit functions as the nucleosome-dependent ATPase, and this protein as the histone chaperone. [provided by RefSeq, Sep 2011]
Transcription factors with Perturb-seq knockdown data for RSF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RSF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RSF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:77,411,314–77,412,382 | 408.9 kb | Distal (>10kb) Multiome | 405 | |
| chr11:77,436,791–77,437,318 | 383.7 kb | Distal (>10kb) Multiome | 44 | |
| chr11:77,473,004–77,474,837 | 346.7 kb | Distal (>10kb) Multiome | 769 | |
| chr11:77,555,382–77,556,090 | 265.0 kb | Distal (>10kb) Multiome | 138 | |
| chr11:77,589,259–77,590,628 | 231.1 kb | Distal (>10kb) Multiome | 830 | |
| chr11:77,637,444–77,638,090 | 183.1 kb | Distal (>10kb) Multiome | 929 | |
| chr11:77,819,354–77,821,704 | 147 bp | At TSS Multiome | 1047 | |
| chr11:77,994,042–77,995,347 | 174.0 kb | Distal (>10kb) Multiome | 908 | |
| chr11:78,022,454–78,023,411 | 202.3 kb | Distal (>10kb) Multiome | 526 | |
| chr11:78,079,393–78,080,040 | 258.9 kb | Distal (>10kb) Multiome | 1033 |
Genomic view of the RSF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.