RSAD1

radical S-adenosyl methionine domain containing 1 | FLJ11164, HemW

Enables heme binding activity. Predicted to be involved in porphyrin-containing compound biosynthetic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Developmental clusters: GC4

Biological processes 12 terms

4 iron, 4 sulfur cluster binding (GO:0051539)4 iron, 4 sulfur cluster binding (GO:0051539)catalytic activity (GO:0003824)coproporphyrinogen oxidase activity (GO:0004109)cytoplasm (GO:0005737)cytoplasm (GO:0005737)heme binding (GO:0020037)iron-sulfur cluster binding (GO:0051536)mitochondrion (GO:0005739)mitochondrion (GO:0005739)porphyrin-containing compound biosynthetic process (GO:0006779)porphyrin-containing compound biosynthetic process (GO:0006779)

Expression (TPM)

TFs regulating RSAD1 0 TFs

Transcription factors with Perturb-seq knockdown data for RSAD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RSAD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RSAD1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RSAD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:50,199,586–50,201,292	278.4 kb	Distal (>10kb) Multiome	798
chr17:50,273,066–50,273,646	205.6 kb	Distal (>10kb) Multiome	411
chr17:50,274,084–50,274,945	204.3 kb	Distal (>10kb) Multiome	242
chr17:50,310,314–50,311,981	167.2 kb	Distal (>10kb) Multiome	314
chr17:50,312,127–50,312,775	166.2 kb	Distal (>10kb) Multiome	37
chr17:50,345,523–50,346,998	132.7 kb	Distal (>10kb) Multiome	809
chr17:50,363,392–50,364,195	115.0 kb	Distal (>10kb) Multiome	164
chr17:50,372,860–50,373,487	105.7 kb	Distal (>10kb) Multiome	999
chr17:50,397,227–50,397,885	81.3 kb	Distal (>10kb) Multiome	1045
chr17:50,425,595–50,426,626	52.6 kb	Distal (>10kb) Multiome	619
chr17:50,478,411–50,479,262	4 bp	At TSS Multiome	956
chr17:50,479,352–50,479,757	493 bp	At TSS	472
chr17:50,482,357–50,482,764	3.5 kb	Proximal (<10kb)	465
chr17:50,508,047–50,508,856	29.6 kb	Distal (>10kb) Multiome	332
chr17:50,541,672–50,542,697	63.3 kb	Distal (>10kb) Multiome	772
chr17:50,546,778–50,547,615	68.3 kb	Distal (>10kb) Multiome	786
chr17:50,558,590–50,561,781	81.7 kb	Distal (>10kb) Multiome	587
chr17:50,586,525–50,587,142	107.9 kb	Distal (>10kb) Multiome	43
chr17:50,634,652–50,635,325	156.2 kb	Distal (>10kb) Multiome	471
chr17:50,707,179–50,708,006	228.8 kb	Distal (>10kb) Multiome	1055
chr17:50,719,167–50,720,018	240.7 kb	Distal (>10kb) Multiome	1050

Genome Browser

Genomic view of the RSAD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.