Enables methylated histone binding activity. Involved in several processes, including cellular response to glucose starvation; intrinsic apoptotic signaling pathway by p53 class mediator; and regulation of gene expression. Acts upstream of with a negative effect on regulation of G1 to G0 transition. Located in several cellular components, including cytosol; nuclear lumen; and rDNA heterochromatin. Part of eNoSc complex. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for RRP8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RRP8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RRP8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:6,318,947–6,321,304 | 284.4 kb | Distal (>10kb) Multiome | 591 | |
| chr11:6,353,367–6,353,932 | 250.1 kb | Distal (>10kb) Multiome | 395 | |
| chr11:6,389,605–6,390,990 | 213.3 kb | Distal (>10kb) Multiome | 752 | |
| chr11:6,405,086–6,405,670 | 198.2 kb | Distal (>10kb) Multiome | 99 | |
| chr11:6,418,399–6,419,618 | 184.6 kb | Distal (>10kb) Multiome | 494 | |
| chr11:6,468,896–6,469,642 | 134.4 kb | Distal (>10kb) Multiome | 253 | |
| chr11:6,473,129–6,474,612 | 129.6 kb | Distal (>10kb) Multiome | 591 | |
| chr11:6,480,885–6,482,114 | 122.2 kb | Distal (>10kb) Multiome | 828 | |
| chr11:6,496,967–6,497,550 | 106.3 kb | Distal (>10kb) Multiome | 71 | |
| chr11:6,586,489–6,587,591 | 16.6 kb | Distal (>10kb) Multiome | 231 | |
| chr11:6,603,192–6,604,726 | 125 bp | At TSS Multiome | 908 | |
| chr11:6,606,600–6,607,433 | 3.5 kb | Proximal (<10kb) Multiome | 532 | |
| chr11:6,611,505–6,613,097 | 8.7 kb | Proximal (<10kb) Multiome | 996 | |
| chr11:6,618,753–6,619,738 | 15.8 kb | Distal (>10kb) Multiome | 587 | |
| chr11:6,629,672–6,631,067 | 26.8 kb | Distal (>10kb) Multiome | 226 | |
| chr11:6,655,068–6,656,298 | 52.2 kb | Distal (>10kb) Multiome | 314 | |
| chr11:6,682,693–6,683,793 | 79.8 kb | Distal (>10kb) Multiome | 950 |
Genomic view of the RRP8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.