This gene encodes a member of the GTR/RAG GTP-binding protein family. The encoded protein is a monomeric guanine nucleotide-binding protein which forms a heterodimer with RRAGA and RRAGB and is primarily localized to the cytoplasm. The encoded protein promotes intracellular localization of the mTOR complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Transcription factors with Perturb-seq knockdown data for RRAGC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RRAGC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RRAGC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:38,012,220–38,013,284 | 847.1 kb | Distal (>10kb) Multiome HiCAR | 1074 | |
| chr1:38,030,338–38,030,974 | 829.3 kb | Distal (>10kb) Multiome HiCAR | 225 | |
| chr1:38,045,344–38,048,035 | 812.8 kb | Distal (>10kb) Multiome HiCAR | 542 | |
| chr1:38,803,885–38,804,528 | 55.5 kb | Distal (>10kb) Multiome | 257 | |
| chr1:38,817,720–38,818,696 | 41.5 kb | Distal (>10kb) Multiome | 375 | |
| chr1:38,856,701–38,856,917 | at TSS | At TSS | 9 | |
| chr1:38,859,087–38,860,584 | 66 bp | At TSS Multiome | 848 | |
| chr1:38,872,771–38,873,884 | 13.7 kb | Distal (>10kb) Multiome | 778 | |
| chr1:38,990,541–38,992,051 | 131.4 kb | Distal (>10kb) Multiome | 902 | |
| chr1:39,025,981–39,026,877 | 166.6 kb | Distal (>10kb) Multiome | 808 | |
| chr1:39,080,764–39,081,936 | 221.4 kb | Distal (>10kb) Multiome | 352 | |
| chr1:39,104,780–39,106,278 | 246.0 kb | Distal (>10kb) Multiome | 621 | |
| chr1:39,132,955–39,133,390 | 273.4 kb | Distal (>10kb) Multiome | 384 |
Genomic view of the RRAGC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.