This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for RPTOR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPTOR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPTOR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:80,260,016–80,260,559 | 284.5 kb | Distal (>10kb) Multiome | 677 | |
| chr17:80,260,789–80,261,746 | 283.3 kb | Distal (>10kb) Multiome | 896 | |
| chr17:80,308,064–80,309,516 | 236.5 kb | Distal (>10kb) Multiome | 193 | |
| chr17:80,376,366–80,377,013 | 168.2 kb | Distal (>10kb) Multiome | 75 | |
| chr17:80,407,766–80,408,220 | 136.9 kb | Distal (>10kb) Multiome | 12 | |
| chr17:80,414,488–80,415,786 | 129.6 kb | Distal (>10kb) Multiome | 964 | |
| chr17:80,426,748–80,427,205 | 117.8 kb | Distal (>10kb) Multiome | 529 | |
| chr17:80,454,454–80,455,448 | 90.0 kb | Distal (>10kb) Multiome | 1002 | |
| chr17:80,475,705–80,477,431 | 68.3 kb | Distal (>10kb) Multiome | 345 | |
| chr17:80,477,689–80,478,296 | 66.6 kb | Distal (>10kb) Multiome | 240 | |
| chr17:80,544,698–80,545,445 | 25 bp | At TSS Multiome | 934 | |
| chr17:80,621,758–80,622,265 | 77.1 kb | Distal (>10kb) Multiome | 97 | |
| chr17:80,833,089–80,833,581 | 288.5 kb | Distal (>10kb) Multiome | 572 |
Genomic view of the RPTOR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.