This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains two non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternative splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for RPS6KA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPS6KA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPS6KA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:166,342,181–166,343,145 | 284.6 kb | Distal (>10kb) Multiome | 976 | |
| chr6:166,381,861–166,384,011 | 244.1 kb | Distal (>10kb) Multiome | 1059 | |
| chr6:166,392,771–166,393,974 | 233.9 kb | Distal (>10kb) Multiome | 201 | |
| chr6:166,551,739–166,552,446 | 75.1 kb | Distal (>10kb) Multiome | 88 | |
| chr6:166,626,261–166,628,806 | 186 bp | At TSS Multiome | 711 | |
| chr6:166,862,101–166,863,325 | 235.4 kb | Distal (>10kb) Multiome | 356 | |
| chr6:166,892,557–166,893,068 | 265.6 kb | Distal (>10kb) Multiome | 11 |
Genomic view of the RPS6KA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.