This gene encodes a protein component of the 60S ribosomal subunit. This protein can bind specifically to domain C of the tax-responsive enhancer element of human T-cell leukemia virus type 1, and may participate in tax-mediated transactivation of transcription. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for RPL6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:112,116,420–112,116,883 | 292.9 kb | Distal (>10kb) Multiome | 549 | |
| chr12:112,125,273–112,125,989 | 284.1 kb | Distal (>10kb) Multiome | 798 | |
| chr12:112,381,577–112,382,895 | 27.2 kb | Distal (>10kb) Multiome | 774 | |
| chr12:112,409,112–112,409,791 | 61 bp | At TSS Multiome | 866 | |
| chr12:112,418,542–112,419,596 | 9.4 kb | Proximal (<10kb) Multiome | 960 | |
| chr12:112,577,793–112,578,332 | 168.5 kb | Distal (>10kb) Multiome | 187 |
Genomic view of the RPL6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.