Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37AE family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C4-type zinc finger-like domain. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RPL37A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL37A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL37A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:216,275,236–216,275,858 | 223.3 kb | Distal (>10kb) Multiome | 120 | |
| chr2:216,283,571–216,284,041 | 215.1 kb | Distal (>10kb) Multiome | 206 | |
| chr2:216,292,640–216,293,553 | 205.7 kb | Distal (>10kb) Multiome | 205 | |
| chr2:216,317,598–216,318,777 | 180.9 kb | Distal (>10kb) Multiome | 193 | |
| chr2:216,339,679–216,340,452 | 158.7 kb | Distal (>10kb) Multiome | 192 | |
| chr2:216,345,559–216,346,320 | 152.9 kb | Distal (>10kb) Multiome | 100 | |
| chr2:216,370,964–216,372,465 | 126.5 kb | Distal (>10kb) Multiome | 850 | |
| chr2:216,412,020–216,413,196 | 86.3 kb | Distal (>10kb) Multiome | 882 | |
| chr2:216,498,326–216,499,289 | 17 bp | At TSS Multiome | 982 | |
| chr2:216,506,891–216,507,541 | 8.1 kb | Proximal (<10kb) | 67 | |
| chr2:216,507,740–216,508,626 | 8.9 kb | Proximal (<10kb) | 79 | |
| chr2:216,606,380–216,607,387 | 108.0 kb | Distal (>10kb) Multiome | 243 | |
| chr2:216,619,507–216,620,419 | 121.1 kb | Distal (>10kb) Multiome | 382 | |
| chr2:216,632,597–216,634,235 | 134.5 kb | Distal (>10kb) Multiome | 459 | |
| chr2:216,635,691–216,637,041 | 138.0 kb | Distal (>10kb) Multiome | 263 | |
| chr2:216,665,266–216,666,969 | 166.9 kb | Distal (>10kb) Multiome | 454 | |
| chr2:216,691,972–216,693,060 | 193.4 kb | Distal (>10kb) Multiome | 383 | |
| chr2:216,694,105–216,695,084 | 195.7 kb | Distal (>10kb) Multiome | 316 | |
| chr2:216,695,439–216,696,027 | 196.9 kb | Distal (>10kb) Multiome | 258 | |
| chr2:216,765,712–216,766,366 | 267.2 kb | Distal (>10kb) Multiome | 240 | |
| chr2:216,777,662–216,778,166 | 279.0 kb | Distal (>10kb) Multiome | 399 | |
| chr2:217,621,957–217,623,171 | 1123.5 kb | Distal (>10kb) Multiome HiCAR | 391 | |
| chr2:217,756,309–217,757,077 | 1257.8 kb | Distal (>10kb) Multiome HiCAR | 391 |
Genomic view of the RPL37A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.