Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L37E family of ribosomal proteins. It is located in the cytoplasm. The protein contains a C2C2-type zinc finger-like motif. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RPL37. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL37 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL37, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:40,678,872–40,680,670 | 155.4 kb | Distal (>10kb) Multiome | 615 | |
| chr5:40,680,710–40,682,280 | 153.6 kb | Distal (>10kb) Multiome | 343 | |
| chr5:40,754,888–40,756,381 | 79.3 kb | Distal (>10kb) Multiome | 1007 | |
| chr5:40,797,344–40,798,944 | 37.0 kb | Distal (>10kb) Multiome | 949 | |
| chr5:40,824,129–40,826,113 | 9.1 kb | Proximal (<10kb) | 416 | |
| chr5:40,826,571–40,827,373 | 7.8 kb | Proximal (<10kb) | 112 | |
| chr5:40,834,732–40,836,235 | 113 bp | At TSS Multiome | 1118 | |
| chr5:40,841,398–40,841,724 | 6.2 kb | Proximal (<10kb) | 285 |
Genomic view of the RPL37 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.