Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 60S subunit. The protein belongs to the L29E family of ribosomal proteins. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin. Although this gene was previously reported to map to 3q29-qter, it is believed that it is located at 3p21.3-p21.2. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RPL29. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL29 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL29, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:51,706,614–51,707,579 | 288.9 kb | Distal (>10kb) Multiome | 506 | |
| chr3:51,798,234–51,798,899 | 197.2 kb | Distal (>10kb) Multiome | 120 | |
| chr3:51,800,441–51,801,024 | 195.3 kb | Distal (>10kb) Multiome | 20 | |
| chr3:51,801,591–51,802,872 | 193.6 kb | Distal (>10kb) Multiome | 223 | |
| chr3:51,868,646–51,869,606 | 126.8 kb | Distal (>10kb) Multiome | 50 | |
| chr3:51,941,340–51,942,909 | 53.8 kb | Distal (>10kb) Multiome | 890 | |
| chr3:51,955,723–51,956,827 | 39.4 kb | Distal (>10kb) Multiome | 289 | |
| chr3:51,967,071–51,968,598 | 28.3 kb | Distal (>10kb) Multiome | 581 | |
| chr3:51,973,571–51,975,404 | 21.9 kb | Distal (>10kb) Multiome | 886 | |
| chr3:51,982,506–51,983,633 | 12.7 kb | Distal (>10kb) Multiome | 933 | |
| chr3:51,990,597–51,991,772 | 4.9 kb | Proximal (<10kb) Multiome | 145 | |
| chr3:51,995,468–51,996,121 | 33 bp | At TSS Multiome | 938 | |
| chr3:52,001,516–52,001,992 | 5.8 kb | Proximal (<10kb) Multiome | 448 | |
| chr3:52,004,292–52,004,541 | 8.4 kb | Proximal (<10kb) | 144 | |
| chr3:52,055,881–52,058,048 | 61.6 kb | Distal (>10kb) Multiome | 937 | |
| chr3:52,128,194–52,128,700 | 132.5 kb | Distal (>10kb) Multiome HiCAR | 376 | |
| chr3:52,153,766–52,155,196 | 158.8 kb | Distal (>10kb) Multiome HiCAR | 896 | |
| chr3:52,197,554–52,198,856 | 202.2 kb | Distal (>10kb) Multiome | 731 | |
| chr3:52,238,767–52,239,716 | 243.3 kb | Distal (>10kb) Multiome | 763 | |
| chr3:52,245,446–52,246,450 | 250.1 kb | Distal (>10kb) Multiome | 553 | |
| chr3:52,277,664–52,279,184 | 282.8 kb | Distal (>10kb) Multiome | 844 | |
| chr3:52,287,499–52,288,336 | 292.0 kb | Distal (>10kb) Multiome | 778 |
Genomic view of the RPL29 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.