Transcription factors with Perturb-seq knockdown data for RPL23AP57. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL23AP57 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL23AP57, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:6,630,579–6,630,752 | 8.4 kb | Proximal (<10kb) | 28 | |
| chr9:6,632,622–6,633,223 | 5.9 kb | Proximal (<10kb) | 202 | |
| chr9:6,645,085–6,646,200 | 5.9 kb | Proximal (<10kb) | 656 | |
| chr9:6,648,431–6,648,592 | 9.3 kb | Proximal (<10kb) | 48 |
Genomic view of the RPL23AP57 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.