RPL23
ribosomal protein L23 | L23, rpL17, uL14

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14P family of ribosomal proteins. It is located in the cytoplasm. This gene has been referred to as rpL17 because the encoded protein shares amino acid identity with ribosomal protein L17 from Saccharomyces cerevisiae; however, its official symbol is RPL23. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Member of: DE-1 DE-1.1 Developmental clusters: GC5
Biological processes 50 terms
G1 to G0 transition (GO:0070314)RNA binding (GO:0003723)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasmic translation (GO:0002181)cytoplasmic translation (GO:0002181)cytoplasmic translation (GO:0002181)cytosol (GO:0005829)cytosol (GO:0005829)cytosolic large ribosomal subunit (GO:0022625)cytosolic large ribosomal subunit (GO:0022625)cytosolic large ribosomal subunit (GO:0022625)cytosolic large ribosomal subunit (GO:0022625)cytosolic ribosome (GO:0022626)extracellular exosome (GO:0070062)focal adhesion (GO:0005925)large ribosomal subunit (GO:0015934)large ribosomal subunit rRNA binding (GO:0070180)membrane (GO:0016020)negative regulation of myoblast fusion (GO:1901740)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of ubiquitin-dependent protein catabolic process (GO:2000059)nucleolus (GO:0005730)nucleolus (GO:0005730)nucleoplasm (GO:0005654)positive regulation of cell population proliferation (GO:0008284)positive regulation of signal transduction by p53 class mediator (GO:1901798)postsynaptic density (GO:0014069)protein binding (GO:0005515)protein stabilization (GO:0050821)protein-DNA complex disassembly (GO:0032986)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)regulation of G1 to G0 transition (GO:1903450)ribosomal protein import into nucleus (GO:0006610)ribosome (GO:0005840)ribosome (GO:0005840)spermatogenesis (GO:0007283)striated muscle contraction (GO:0006941)structural constituent of ribosome (GO:0003735)structural constituent of ribosome (GO:0003735)structural constituent of ribosome (GO:0003735)structural constituent of ribosome (GO:0003735)synapse (GO:0045202)transcription coactivator binding (GO:0001223)translation (GO:0006412)translation (GO:0006412)ubiquitin ligase inhibitor activity (GO:1990948)ubiquitin protein ligase binding (GO:0031625)
Expression (TPM)
RPL23 — as a Regulated Gene

TFs regulating RPL23 0 TFs

Transcription factors with Perturb-seq knockdown data for RPL23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to RPL23

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:38,558,106–38,558,652 295.4 kb Distal (>10kb) Multiome 631
chr17:38,559,205–38,559,900 294.1 kb Distal (>10kb) Multiome 598
chr17:38,572,553–38,573,232 280.8 kb Distal (>10kb) Multiome 231
chr17:38,604,448–38,605,250 248.9 kb Distal (>10kb) Multiome 375
chr17:38,605,359–38,606,888 247.3 kb Distal (>10kb) Multiome 781
chr17:38,609,172–38,610,061 244.1 kb Distal (>10kb) Multiome 229
chr17:38,673,658–38,675,315 178.8 kb Distal (>10kb) Multiome 847
chr17:38,701,857–38,703,072 151.4 kb Distal (>10kb) Multiome 907
chr17:38,703,568–38,704,668 149.8 kb Distal (>10kb) Multiome 955
chr17:38,704,725–38,707,220 148.4 kb Distal (>10kb) Multiome 784
chr17:38,718,492–38,719,127 135.0 kb Distal (>10kb) Multiome 268
chr17:38,719,228–38,720,635 133.5 kb Distal (>10kb) Multiome 290
chr17:38,729,824–38,730,713 123.5 kb Distal (>10kb) Multiome 794
chr17:38,747,498–38,750,334 103.9 kb Distal (>10kb) Multiome 914
chr17:38,751,747–38,753,201 102.0 kb Distal (>10kb) Multiome 986
chr17:38,789,155–38,789,604 64.4 kb Distal (>10kb) Multiome 144
chr17:38,798,912–38,800,293 53.8 kb Distal (>10kb) Multiome 966
chr17:38,824,673–38,825,720 28.4 kb Distal (>10kb) Multiome 978
chr17:38,853,382–38,854,144 35 bp At TSS Multiome 1047
chr17:38,867,391–38,868,381 13.9 kb Distal (>10kb) Multiome 640
chr17:38,869,253–38,871,194 16.0 kb Distal (>10kb) Multiome 1074
chr17:38,900,769–38,901,637 47.6 kb Distal (>10kb) Multiome 370
chr17:38,967,321–38,967,861 113.8 kb Distal (>10kb) Multiome 219
chr17:39,011,896–39,012,455 158.4 kb Distal (>10kb) Multiome 81
chr17:39,056,695–39,057,296 203.2 kb Distal (>10kb) Multiome 468
chr17:39,152,575–39,154,848 299.2 kb Distal (>10kb) Multiome 1041

Genome Browser

Genomic view of the RPL23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:38,548,106 – 39,164,848
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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