This gene encodes a ribosomal protein that is a component of the 60S ribosome subunit. The related protein in chicken can bind to c-Jun and can repress c-Jun-mediated transcriptional activation. Some studies have detected an association between variation in this gene and autism spectrum disorders, though others do not detect this relationship. There are multiple pseudogenes of this gene dispersed throughout the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for RPL10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RPL10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RPL10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:154,136,648–154,137,146 | 261.5 kb | Distal (>10kb) Multiome | 391 | |
| chrX:154,368,993–154,370,053 | 28.8 kb | Distal (>10kb) Multiome | 546 | |
| chrX:154,370,757–154,372,188 | 27.0 kb | Distal (>10kb) Multiome | 764 | |
| chrX:154,378,063–154,379,701 | 19.4 kb | Distal (>10kb) Multiome | 687 | |
| chrX:154,397,430–154,398,941 | 139 bp | At TSS Multiome | 871 | |
| chrX:154,409,052–154,409,671 | 11.0 kb | Distal (>10kb) Multiome | 396 | |
| chrX:154,428,419–154,428,969 | 30.3 kb | Distal (>10kb) Multiome | 601 | |
| chrX:154,436,501–154,437,435 | 38.6 kb | Distal (>10kb) Multiome | 448 | |
| chrX:154,443,986–154,444,454 | 45.8 kb | Distal (>10kb) Multiome | 329 | |
| chrX:154,457,605–154,458,763 | 59.7 kb | Distal (>10kb) Multiome | 467 | |
| chrX:154,478,385–154,479,590 | 80.7 kb | Distal (>10kb) Multiome | 707 | |
| chrX:154,486,385–154,487,035 | 88.4 kb | Distal (>10kb) Multiome | 437 | |
| chrX:154,490,259–154,491,245 | 92.4 kb | Distal (>10kb) Multiome | 567 | |
| chrX:154,515,811–154,517,059 | 118.0 kb | Distal (>10kb) Multiome | 590 | |
| chrX:154,546,514–154,547,906 | 148.8 kb | Distal (>10kb) Multiome | 691 |
Genomic view of the RPL10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.