Predicted to enable pre-mRNA 5'-splice site binding activity. Predicted to be involved in mRNA 5'-splice site recognition. Predicted to be part of U1 snRNP. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNVU1-18. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNVU1-18 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNVU1-18, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:143,719,885–143,721,132 | 8.4 kb | Proximal (<10kb) | 433 | |
| chr1:143,724,138–143,724,684 | 4.9 kb | Proximal (<10kb) | 60 | |
| chr1:143,728,908–143,729,108 | 461 bp | At TSS | 13 | |
| chr1:143,729,456–143,729,857 | at TSS | At TSS | 101 | |
| chr1:143,735,660–143,736,870 | 6.1 kb | Proximal (<10kb) | 191 |
Genomic view of the RNVU1-18 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.