Enables several functions, including NADH binding activity; epinephrine binding activity; and monoamine oxidase activity. Involved in negative regulation of blood pressure and negative regulation of heart rate. Located in extracellular region. Implicated in essential hypertension and hypertension. Biomarker of end stage renal disease. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNLS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNLS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNLS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:87,861,521–87,864,430 | 719.8 kb | Distal (>10kb) Multiome HiCAR | 1208 | |
| chr10:88,371,648–88,372,566 | 211.1 kb | Distal (>10kb) Multiome | 115 | |
| chr10:88,375,677–88,376,274 | 207.2 kb | Distal (>10kb) Multiome | 61 | |
| chr10:88,582,470–88,583,714 | 168 bp | At TSS Multiome | 465 | |
| chr10:88,702,897–88,703,854 | 120.1 kb | Distal (>10kb) Multiome | 410 | |
| chr10:88,728,234–88,729,081 | 145.3 kb | Distal (>10kb) Multiome | 223 | |
| chr10:88,879,874–88,881,155 | 297.3 kb | Distal (>10kb) Multiome | 837 |
Genomic view of the RNLS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.