Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]
Transcription factors with Perturb-seq knockdown data for RNH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:206,950–208,051 | 299.8 kb | Distal (>10kb) Multiome | 884 | |
| chr11:208,471–209,205 | 298.4 kb | Distal (>10kb) Multiome | 593 | |
| chr11:235,864–237,255 | 270.7 kb | Distal (>10kb) Multiome | 874 | |
| chr11:288,466–289,320 | 218.2 kb | Distal (>10kb) Multiome | 400 | |
| chr11:313,383–314,476 | 193.3 kb | Distal (>10kb) Multiome | 421 | |
| chr11:316,978–318,064 | 190.0 kb | Distal (>10kb) Multiome | 100 | |
| chr11:333,722–334,610 | 173.0 kb | Distal (>10kb) Multiome | 238 | |
| chr11:355,654–356,479 | 151.0 kb | Distal (>10kb) Multiome | 894 | |
| chr11:370,037–370,556 | 137.0 kb | Distal (>10kb) Multiome | 205 | |
| chr11:406,008–408,661 | 100.0 kb | Distal (>10kb) Multiome | 587 | |
| chr11:416,764–417,613 | 89.9 kb | Distal (>10kb) Multiome | 431 | |
| chr11:447,919–448,752 | 59.0 kb | Distal (>10kb) Multiome | 808 | |
| chr11:449,838–451,194 | 57.0 kb | Distal (>10kb) Multiome | 836 | |
| chr11:506,153–507,989 | 65 bp | At TSS Multiome | 977 | |
| chr11:534,525–536,399 | 28.4 kb | Distal (>10kb) Multiome | 673 | |
| chr11:536,654–537,918 | 30.2 kb | Distal (>10kb) Multiome | 558 | |
| chr11:554,380–556,321 | 47.9 kb | Distal (>10kb) Multiome | 460 | |
| chr11:559,830–562,079 | 53.6 kb | Distal (>10kb) Multiome | 791 | |
| chr11:567,850–569,533 | 61.4 kb | Distal (>10kb) Multiome | 672 | |
| chr11:574,830–576,748 | 68.9 kb | Distal (>10kb) Multiome | 793 | |
| chr11:613,334–614,059 | 106.5 kb | Distal (>10kb) Multiome | 215 | |
| chr11:615,262–616,320 | 108.7 kb | Distal (>10kb) Multiome | 443 | |
| chr11:636,786–637,700 | 129.9 kb | Distal (>10kb) Multiome | 161 | |
| chr11:693,835–696,330 | 188.2 kb | Distal (>10kb) Multiome | 873 | |
| chr11:705,737–706,270 | 198.8 kb | Distal (>10kb) Multiome | 361 | |
| chr11:720,619–721,074 | 213.7 kb | Distal (>10kb) Multiome | 156 | |
| chr11:727,901–728,499 | 221.0 kb | Distal (>10kb) Multiome | 686 | |
| chr11:746,704–748,069 | 240.1 kb | Distal (>10kb) Multiome | 755 | |
| chr11:762,582–763,602 | 256.1 kb | Distal (>10kb) Multiome | 326 | |
| chr11:776,216–778,328 | 270.2 kb | Distal (>10kb) Multiome | 770 | |
| chr11:783,385–783,909 | 276.5 kb | Distal (>10kb) Multiome | 278 | |
| chr11:797,112–798,675 | 291.0 kb | Distal (>10kb) Multiome | 697 | |
| chr11:804,241–805,812 | 298.1 kb | Distal (>10kb) Multiome | 725 |
Genomic view of the RNH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.