This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for RNF24. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF24 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF24, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:3,732,150–3,733,030 | 283.0 kb | Distal (>10kb) Multiome | 192 | |
| chr20:3,744,813–3,745,795 | 270.4 kb | Distal (>10kb) Multiome | 379 | |
| chr20:3,749,619–3,750,251 | 265.6 kb | Distal (>10kb) Multiome | 520 | |
| chr20:3,751,352–3,752,738 | 263.4 kb | Distal (>10kb) Multiome | 261 | |
| chr20:3,767,155–3,768,879 | 247.6 kb | Distal (>10kb) Multiome | 1011 | |
| chr20:3,777,516–3,778,624 | 237.4 kb | Distal (>10kb) Multiome | 428 | |
| chr20:3,781,161–3,781,797 | 234.1 kb | Distal (>10kb) Multiome | 595 | |
| chr20:3,785,713–3,787,025 | 228.8 kb | Distal (>10kb) Multiome | 695 | |
| chr20:3,795,543–3,796,972 | 219.4 kb | Distal (>10kb) Multiome | 925 | |
| chr20:3,799,527–3,800,087 | 215.8 kb | Distal (>10kb) Multiome | 197 | |
| chr20:3,820,073–3,821,115 | 195.0 kb | Distal (>10kb) Multiome | 1081 | |
| chr20:3,846,214–3,847,496 | 168.7 kb | Distal (>10kb) Multiome | 940 | |
| chr20:3,875,544–3,876,019 | 139.7 kb | Distal (>10kb) Multiome | 80 | |
| chr20:3,888,329–3,890,033 | 126.4 kb | Distal (>10kb) Multiome | 1031 | |
| chr20:4,014,730–4,016,019 | 56 bp | At TSS Multiome | 865 | |
| chr20:4,022,679–4,023,089 | 7.1 kb | Proximal (<10kb) | 107 | |
| chr20:4,064,484–4,064,955 | 49.1 kb | Distal (>10kb) Multiome | 290 | |
| chr20:4,082,773–4,083,490 | 67.6 kb | Distal (>10kb) Multiome | 445 | |
| chr20:4,085,118–4,085,823 | 69.9 kb | Distal (>10kb) Multiome | 674 | |
| chr20:4,108,490–4,109,121 | 93.2 kb | Distal (>10kb) Multiome | 600 | |
| chr20:4,148,342–4,150,081 | 133.2 kb | Distal (>10kb) Multiome | 657 | |
| chr20:4,165,766–4,166,634 | 150.5 kb | Distal (>10kb) Multiome | 108 | |
| chr20:4,171,885–4,173,010 | 157.0 kb | Distal (>10kb) Multiome | 928 | |
| chr20:4,221,217–4,222,225 | 206.0 kb | Distal (>10kb) Multiome | 530 | |
| chr20:4,248,848–4,250,016 | 234.0 kb | Distal (>10kb) Multiome | 591 |
Genomic view of the RNF24 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.