RNF167

ring finger protein 167 | DKFZP566H073

RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]

Member of: DE-1

Biological processes 36 terms

cellular response to leucine starvation (GO:1990253)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)endolysosome membrane (GO:0036020)endomembrane system (GO:0012505)endosome (GO:0005768)endosome (GO:0005768)endosome membrane (GO:0010008)lysosomal membrane (GO:0005765)lysosomal membrane (GO:0005765)lysosome (GO:0005764)lysosome localization (GO:0032418)lysosome localization (GO:0032418)negative regulation of TORC1 signaling (GO:1904262)negative regulation of cell cycle (GO:0045786)negative regulation of cell cycle (GO:0045786)negative regulation of intracellular signal transduction (GO:1902532)organelle localization (GO:0051640)plasma membrane (GO:0005886)positive regulation of TORC1 signaling (GO:1904263)protein K29-linked ubiquitination (GO:0035519)protein K63-linked ubiquitination (GO:0070534)protein binding (GO:0005515)protein polyubiquitination (GO:0000209)protein ubiquitination (GO:0016567)regulation of synaptic transmission, glutamatergic (GO:0051966)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin protein ligase activity (GO:0061630)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-dependent protein catabolic process (GO:0006511)ubiquitin-protein transferase activity (GO:0004842)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating RNF167 0 TFs

Transcription factors with Perturb-seq knockdown data for RNF167. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF167 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RNF167

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF167, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:4,703,669–4,704,637	236.0 kb	Distal (>10kb) Multiome	854
chr17:4,708,553–4,709,232	231.4 kb	Distal (>10kb) Multiome	71
chr17:4,709,724–4,711,094	229.6 kb	Distal (>10kb) Multiome	771
chr17:4,730,794–4,732,115	208.5 kb	Distal (>10kb) Multiome	936
chr17:4,745,124–4,745,511	194.6 kb	Distal (>10kb) Multiome	67
chr17:4,789,618–4,790,520	149.9 kb	Distal (>10kb) Multiome	816
chr17:4,795,974–4,796,433	143.9 kb	Distal (>10kb) Multiome	751
chr17:4,806,693–4,807,619	133.0 kb	Distal (>10kb) Multiome	494
chr17:4,832,863–4,833,956	106.7 kb	Distal (>10kb) Multiome	730
chr17:4,898,962–4,900,112	40.6 kb	Distal (>10kb) Multiome	257
chr17:4,900,249–4,901,057	39.3 kb	Distal (>10kb) Multiome	145
chr17:4,909,117–4,909,538	30.8 kb	Distal (>10kb) Multiome	553
chr17:4,939,475–4,941,034	95 bp	At TSS Multiome	821
chr17:4,947,426–4,950,636	10.1 kb	Distal (>10kb) Multiome	1080
chr17:4,966,739–4,968,875	27.5 kb	Distal (>10kb) Multiome	982
chr17:4,986,950–4,987,983	47.5 kb	Distal (>10kb) Multiome	881
chr17:4,996,838–4,998,964	57.6 kb	Distal (>10kb) Multiome	759
chr17:5,031,487–5,032,081	91.6 kb	Distal (>10kb) Multiome	342
chr17:5,111,339–5,112,612	171.9 kb	Distal (>10kb) Multiome	864
chr17:5,191,578–5,192,305	251.8 kb	Distal (>10kb) Multiome	771

Genome Browser

Genomic view of the RNF167 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.