Enables small GTPase binding activity and ubiquitin protein ligase activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and protein ubiquitination. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNF152. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF152 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF152, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:59,898,933–59,901,245 | 1994.4 kb | Distal (>10kb) Multiome HiCAR | 872 | |
| chr18:59,937,643–59,938,291 | 1956.3 kb | Distal (>10kb) Multiome HiCAR | 187 | |
| chr18:61,581,509–61,582,612 | 312.2 kb | Distal (>10kb) Multiome HiCAR | 366 | |
| chr18:61,606,079–61,607,265 | 287.5 kb | Distal (>10kb) Multiome HiCAR | 389 | |
| chr18:61,635,694–61,637,010 | 258.0 kb | Distal (>10kb) Multiome HiCAR | 290 | |
| chr18:61,637,905–61,638,561 | 256.2 kb | Distal (>10kb) Multiome HiCAR | 176 | |
| chr18:61,653,730–61,654,655 | 240.2 kb | Distal (>10kb) Multiome | 93 | |
| chr18:61,692,095–61,692,905 | 201.8 kb | Distal (>10kb) Multiome | 47 | |
| chr18:61,709,760–61,710,820 | 183.9 kb | Distal (>10kb) Multiome | 155 | |
| chr18:61,790,226–61,791,865 | 102.8 kb | Distal (>10kb) Multiome | 169 | |
| chr18:61,892,652–61,895,395 | 273 bp | At TSS Multiome | 584 | |
| chr18:61,901,055–61,901,701 | 6.8 kb | Proximal (<10kb) | 181 | |
| chr18:62,186,068–62,188,297 | 292.9 kb | Distal (>10kb) Multiome | 884 |
Genomic view of the RNF152 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.