Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within cellular response to xenobiotic stimulus; negative regulation of MAPK cascade; and regulation of protein stability. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNF149. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF149 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF149, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:101,150,573–101,153,105 | 157.3 kb | Distal (>10kb) Multiome | 881 | |
| chr2:101,249,749–101,250,223 | 58.7 kb | Distal (>10kb) Multiome | 50 | |
| chr2:101,251,158–101,251,706 | 57.3 kb | Distal (>10kb) Multiome | 97 | |
| chr2:101,251,848–101,253,677 | 56.0 kb | Distal (>10kb) Multiome | 1083 | |
| chr2:101,307,900–101,309,246 | 46 bp | At TSS Multiome | 997 | |
| chr2:101,386,609–101,387,979 | 78.7 kb | Distal (>10kb) Multiome | 493 | |
| chr2:101,473,856–101,474,832 | 165.6 kb | Distal (>10kb) Multiome | 326 |
Genomic view of the RNF149 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.