Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ERAD pathway and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endomembrane system. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RNF145. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF145 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF145, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:158,951,665–158,952,451 | 257.4 kb | Distal (>10kb) Multiome | 162 | |
| chr5:159,099,838–159,101,146 | 109.1 kb | Distal (>10kb) Multiome | 500 | |
| chr5:159,207,786–159,208,574 | 978 bp | At TSS | 642 | |
| chr5:159,208,643–159,210,083 | 61 bp | At TSS Multiome | 898 | |
| chr5:159,262,736–159,263,791 | 53.7 kb | Distal (>10kb) Multiome | 849 | |
| chr5:159,331,221–159,332,012 | 122.1 kb | Distal (>10kb) Multiome | 487 | |
| chr5:159,416,519–159,417,760 | 207.8 kb | Distal (>10kb) Multiome | 142 | |
| chr5:159,442,094–159,442,787 | 233.0 kb | Distal (>10kb) Multiome | 60 | |
| chr5:159,510,131–159,510,890 | 300.9 kb | Distal (>10kb) Multiome | 235 |
Genomic view of the RNF145 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.