This gene encodes a member of a family of RING finger domain-containing E3 ubiquitin ligases that also includes parkin and parc. The expression of this gene is induced by DNA damage. The encoded protein interacts with the cytoplasmic DNA-dependent protein kinase, catalytic subunit (DNA-PKcs) and promotes its degradation through ubiquitination. The orthologous mouse protein has been shown to interact with a ubiquitin-conjugating enzyme involved in embryonic development. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for RNF144A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF144A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF144A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:5,120,971–5,122,162 | 1795.7 kb | Distal (>10kb) Multiome HiCAR | 150 | |
| chr2:6,639,871–6,640,946 | 277.4 kb | Distal (>10kb) Multiome | 180 | |
| chr2:6,864,891–6,866,663 | 51.7 kb | Distal (>10kb) Multiome | 798 | |
| chr2:6,916,839–6,918,478 | 33 bp | At TSS Multiome | 612 | |
| chr2:6,918,591–6,919,320 | 1.1 kb | Proximal (<10kb) | 225 | |
| chr2:6,922,479–6,922,799 | 5.0 kb | Proximal (<10kb) | 172 |
Genomic view of the RNF144A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.