The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RNF139. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF139 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF139, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:123,240,791–123,241,581 | 1233.5 kb | Distal (>10kb) Multiome HiCAR | 784 | |
| chr8:123,767,780–123,769,038 | 706.5 kb | Distal (>10kb) Multiome HiCAR | 744 | |
| chr8:124,223,096–124,223,793 | 251.5 kb | Distal (>10kb) Multiome | 60 | |
| chr8:124,235,723–124,236,382 | 238.9 kb | Distal (>10kb) Multiome | 107 | |
| chr8:124,371,408–124,373,569 | 102.1 kb | Distal (>10kb) Multiome | 891 | |
| chr8:124,425,336–124,426,470 | 48.7 kb | Distal (>10kb) Multiome | 332 | |
| chr8:124,465,779–124,466,060 | 8.8 kb | Proximal (<10kb) | 51 | |
| chr8:124,473,813–124,475,636 | 104 bp | At TSS Multiome | 970 | |
| chr8:124,476,092–124,476,472 | 1.2 kb | Proximal (<10kb) | 287 | |
| chr8:124,538,847–124,539,474 | 64.2 kb | Distal (>10kb) Multiome | 921 | |
| chr8:124,635,289–124,635,776 | 160.7 kb | Distal (>10kb) Multiome | 230 | |
| chr8:124,726,992–124,728,984 | 253.7 kb | Distal (>10kb) Multiome | 609 |
Genomic view of the RNF139 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.