The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RNF138. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF138 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF138, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:31,825,470–31,827,414 | 265.1 kb | Distal (>10kb) Multiome | 319 | |
| chr18:31,942,190–31,943,930 | 148.6 kb | Distal (>10kb) Multiome | 1005 | |
| chr18:31,946,388–31,947,273 | 145.1 kb | Distal (>10kb) Multiome | 158 | |
| chr18:32,018,028–32,020,301 | 73.4 kb | Distal (>10kb) Multiome | 961 | |
| chr18:32,022,264–32,023,296 | 69.1 kb | Distal (>10kb) Multiome | 94 | |
| chr18:32,091,522–32,093,539 | 648 bp | At TSS Multiome | 1047 | |
| chr18:32,157,719–32,158,676 | 66.4 kb | Distal (>10kb) Multiome | 433 |
Genomic view of the RNF138 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.