The protein encoded by this gene contains a RING finger motif and is similar to g1, a Drosophila zinc-finger protein that is expressed in mesoderm and involved in embryonic development. The expression of the mouse counterpart was found to be upregulated in myeloblastic cells following IL3 deprivation, suggesting that this gene may regulate growth factor withdrawal-induced apoptosis of myeloid precursor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for RNF130. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF130 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF130, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:179,795,059–179,796,988 | 275.9 kb | Distal (>10kb) Multiome | 778 | |
| chr5:179,805,642–179,807,610 | 265.2 kb | Distal (>10kb) Multiome | 747 | |
| chr5:179,818,809–179,822,095 | 251.2 kb | Distal (>10kb) Multiome | 1243 | |
| chr5:179,858,283–179,859,465 | 213.2 kb | Distal (>10kb) Multiome | 923 | |
| chr5:179,907,372–179,908,268 | 164.2 kb | Distal (>10kb) Multiome | 528 | |
| chr5:180,007,647–180,008,169 | 64.3 kb | Distal (>10kb) Multiome | 251 | |
| chr5:180,059,605–180,060,144 | 12.3 kb | Distal (>10kb) Multiome | 18 | |
| chr5:180,069,680–180,070,372 | 2.2 kb | Proximal (<10kb) Multiome | 240 | |
| chr5:180,071,104–180,072,473 | 130 bp | At TSS Multiome | 1084 | |
| chr5:180,090,117–180,091,054 | 18.4 kb | Distal (>10kb) Multiome | 575 | |
| chr5:180,208,671–180,209,518 | 137.1 kb | Distal (>10kb) Multiome | 385 | |
| chr5:180,291,390–180,292,854 | 220.0 kb | Distal (>10kb) Multiome | 694 | |
| chr5:180,292,972–180,293,953 | 221.5 kb | Distal (>10kb) Multiome | 556 | |
| chr5:180,352,255–180,354,009 | 281.4 kb | Distal (>10kb) Multiome | 450 |
Genomic view of the RNF130 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.