The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Several alternatively spliced transcript variants have been noted for this gene, however, not all are likely to encode viable protein products. [provided by RefSeq, Sep 2008]
Transcription factors with Perturb-seq knockdown data for RNF121. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF121 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF121, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:71,750,971–71,751,686 | 177.8 kb | Distal (>10kb) Multiome | 86 | |
| chr11:71,786,388–71,787,283 | 142.0 kb | Distal (>10kb) Multiome | 289 | |
| chr11:71,928,161–71,929,328 | 165 bp | At TSS Multiome | 869 | |
| chr11:72,040,697–72,041,585 | 112.0 kb | Distal (>10kb) Multiome | 586 | |
| chr11:72,080,144–72,081,188 | 151.6 kb | Distal (>10kb) Multiome | 789 | |
| chr11:72,088,078–72,088,746 | 159.3 kb | Distal (>10kb) Multiome | 50 | |
| chr11:72,102,846–72,104,062 | 174.3 kb | Distal (>10kb) Multiome | 870 | |
| chr11:72,111,979–72,113,129 | 183.5 kb | Distal (>10kb) Multiome | 901 | |
| chr11:72,222,505–72,225,138 | 294.3 kb | Distal (>10kb) Multiome | 815 |
Genomic view of the RNF121 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.