RNASEK

ribonuclease K | MGC71993

Enables RNA endonuclease activity. Involved in endosomal lumen acidification; proton transmembrane transport; and receptor-mediated endocytosis of virus by host cell. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1 DE-1.6 Developmental clusters: GC7

Biological processes 22 terms

Golgi lumen acidification (GO:0061795)Golgi membrane (GO:0000139)RNA endonuclease activity (GO:0004521)RNA endonuclease activity (GO:0004521)RNA endonuclease activity (GO:0004521)clathrin-coated vesicle membrane (GO:0030665)endomembrane system (GO:0012505)endosomal lumen acidification (GO:0048388)endosomal lumen acidification (GO:0048388)endosome membrane (GO:0010008)intracellular pH reduction (GO:0051452)lysosomal lumen acidification (GO:0007042)lysosomal membrane (GO:0005765)membrane (GO:0016020)plasma membrane (GO:0005886)protein binding (GO:0005515)proton transmembrane transport (GO:1902600)proton transmembrane transport (GO:1902600)receptor-mediated endocytosis (GO:0006898)receptor-mediated endocytosis of virus by host cell (GO:0019065)vacuolar acidification (GO:0007035)vacuolar proton-transporting V-type ATPase, V0 domain (GO:0000220)

Expression (TPM)

TFs regulating RNASEK 0 TFs

Transcription factors with Perturb-seq knockdown data for RNASEK. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNASEK upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RNASEK

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNASEK, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr17:6,650,954–6,652,333	361.0 kb	Distal (>10kb) Multiome HiCAR	949
chr17:6,713,294–6,714,088	299.0 kb	Distal (>10kb) Multiome	535
chr17:6,831,647–6,832,107	180.8 kb	Distal (>10kb) Multiome	202
chr17:6,995,886–6,996,299	16.7 kb	Distal (>10kb) Multiome	124
chr17:7,012,245–7,012,890	108 bp	At TSS Multiome	804
chr17:7,014,335–7,015,213	2.2 kb	Proximal (<10kb) Multiome	842
chr17:7,019,807–7,020,192	7.2 kb	Proximal (<10kb)	234
chr17:7,021,831–7,024,265	11.2 kb	Distal (>10kb) Multiome	614
chr17:7,035,527–7,036,637	23.3 kb	Distal (>10kb) Multiome	791
chr17:7,132,532–7,133,109	120.2 kb	Distal (>10kb) Multiome	312
chr17:7,177,263–7,177,909	164.9 kb	Distal (>10kb) Multiome	453
chr17:7,204,820–7,205,551	192.5 kb	Distal (>10kb) Multiome	364
chr17:7,207,943–7,208,476	195.6 kb	Distal (>10kb) Multiome	91
chr17:7,213,858–7,216,461	201.9 kb	Distal (>10kb) Multiome	737
chr17:7,219,603–7,220,515	207.3 kb	Distal (>10kb) Multiome	793
chr17:7,233,847–7,235,210	221.9 kb	Distal (>10kb) Multiome	1020
chr17:7,237,531–7,238,757	225.3 kb	Distal (>10kb) Multiome	502
chr17:7,238,867–7,240,155	227.1 kb	Distal (>10kb) Multiome	783
chr17:7,241,494–7,243,462	230.4 kb	Distal (>10kb) Multiome	1037
chr17:7,251,263–7,252,962	239.5 kb	Distal (>10kb) Multiome	985
chr17:7,260,746–7,263,748	250.0 kb	Distal (>10kb) Multiome	639
chr17:7,280,161–7,282,555	269.0 kb	Distal (>10kb) Multiome	841
chr17:7,293,901–7,295,189	282.1 kb	Distal (>10kb) Multiome	443
chr17:7,296,224–7,296,683	283.9 kb	Distal (>10kb) Multiome	688
chr17:7,306,788–7,309,027	294.8 kb	Distal (>10kb) Multiome	896

Genome Browser

Genomic view of the RNASEK locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.