This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RNASEH2C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNASEH2C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNASEH2C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:65,421,858–65,423,533 | 298.4 kb | Distal (>10kb) Multiome | 1197 | |
| chr11:65,454,735–65,455,360 | 265.6 kb | Distal (>10kb) Multiome | 573 | |
| chr11:65,477,100–65,477,990 | 243.2 kb | Distal (>10kb) Multiome | 991 | |
| chr11:65,487,451–65,488,490 | 233.0 kb | Distal (>10kb) Multiome | 706 | |
| chr11:65,496,515–65,498,726 | 223.2 kb | Distal (>10kb) Multiome | 1059 | |
| chr11:65,506,702–65,508,865 | 213.5 kb | Distal (>10kb) Multiome | 864 | |
| chr11:65,524,475–65,525,724 | 195.8 kb | Distal (>10kb) Multiome | 711 | |
| chr11:65,538,923–65,541,339 | 180.0 kb | Distal (>10kb) Multiome | 733 | |
| chr11:65,546,285–65,547,091 | 174.1 kb | Distal (>10kb) Multiome | 529 | |
| chr11:65,553,318–65,554,003 | 167.1 kb | Distal (>10kb) Multiome | 195 | |
| chr11:65,569,718–65,570,745 | 150.5 kb | Distal (>10kb) Multiome | 930 | |
| chr11:65,571,973–65,573,008 | 148.3 kb | Distal (>10kb) Multiome | 420 | |
| chr11:65,573,788–65,575,269 | 146.5 kb | Distal (>10kb) Multiome | 742 | |
| chr11:65,575,601–65,576,322 | 144.8 kb | Distal (>10kb) Multiome | 527 | |
| chr11:65,591,808–65,592,698 | 128.6 kb | Distal (>10kb) Multiome | 169 | |
| chr11:65,606,536–65,607,917 | 113.6 kb | Distal (>10kb) Multiome | 376 | |
| chr11:65,613,478–65,614,645 | 106.6 kb | Distal (>10kb) Multiome | 702 | |
| chr11:65,614,954–65,616,793 | 105.3 kb | Distal (>10kb) Multiome | 830 | |
| chr11:65,637,768–65,638,920 | 82.7 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,641,918–65,642,633 | 78.6 kb | Distal (>10kb) Multiome | 155 | |
| chr11:65,646,814–65,647,818 | 73.5 kb | Distal (>10kb) Multiome | 270 | |
| chr11:65,652,106–65,653,317 | 68.1 kb | Distal (>10kb) Multiome | 901 | |
| chr11:65,662,517–65,663,930 | 57.7 kb | Distal (>10kb) Multiome | 839 | |
| chr11:65,711,437–65,712,942 | 8.5 kb | Proximal (<10kb) Multiome | 1143 | |
| chr11:65,720,215–65,720,955 | 125 bp | At TSS Multiome | 821 | |
| chr11:65,779,808–65,781,988 | 59.3 kb | Distal (>10kb) Multiome | 764 | |
| chr11:65,785,898–65,789,101 | 67.6 kb | Distal (>10kb) Multiome | 478 | |
| chr11:65,817,968–65,818,502 | 97.5 kb | Distal (>10kb) Multiome HiCAR | 694 | |
| chr11:65,833,325–65,834,189 | 113.0 kb | Distal (>10kb) Multiome | 396 | |
| chr11:65,856,804–65,858,748 | 136.3 kb | Distal (>10kb) Multiome | 972 | |
| chr11:65,859,034–65,861,240 | 139.8 kb | Distal (>10kb) Multiome | 1012 | |
| chr11:65,871,920–65,874,072 | 152.9 kb | Distal (>10kb) Multiome | 741 | |
| chr11:65,887,987–65,889,162 | 167.8 kb | Distal (>10kb) Multiome | 824 | |
| chr11:65,890,253–65,891,457 | 169.8 kb | Distal (>10kb) Multiome | 895 | |
| chr11:65,899,867–65,900,779 | 179.8 kb | Distal (>10kb) Multiome | 740 | |
| chr11:65,918,507–65,920,266 | 198.4 kb | Distal (>10kb) Multiome | 992 | |
| chr11:65,961,271–65,962,172 | 240.9 kb | Distal (>10kb) Multiome | 834 | |
| chr11:66,001,882–66,002,962 | 281.6 kb | Distal (>10kb) Multiome | 1022 | |
| chr11:66,007,227–66,007,703 | 286.7 kb | Distal (>10kb) Multiome | 100 |
Genomic view of the RNASEH2C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.