Predicted to enable nucleotide binding activity. Involved in double-strand break repair via homologous recombination and resolution of DNA recombination intermediates. Located in nuclear body. Part of RecQ family helicase-topoisomerase III complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RMI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RMI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RMI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:83,706,859–83,708,822 | 273.6 kb | Distal (>10kb) Multiome | 1068 | |
| chr9:83,817,135–83,818,401 | 163.0 kb | Distal (>10kb) Multiome | 350 | |
| chr9:83,920,675–83,922,066 | 59.4 kb | Distal (>10kb) Multiome | 895 | |
| chr9:83,956,086–83,957,142 | 24.0 kb | Distal (>10kb) Multiome | 869 | |
| chr9:83,979,201–83,981,658 | 242 bp | At TSS Multiome | 1059 | |
| chr9:84,255,310–84,256,754 | 275.1 kb | Distal (>10kb) Multiome HiCAR | 151 |
Genomic view of the RMI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.