MINA is a c-Myc (MYC; MIM 190080) target gene that may play a role in cell proliferation or regulation of cell growth. (Tsuneoka et al., 2002 [PubMed 12091391]; Zhang et al., 2005 [PubMed 15897898]).[supplied by OMIM, May 2008]
Transcription factors with Perturb-seq knockdown data for RIOX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIOX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIOX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:97,763,818–97,765,461 | 207.5 kb | Distal (>10kb) Multiome | 720 | |
| chr3:97,821,200–97,822,852 | 150.1 kb | Distal (>10kb) Multiome | 747 | |
| chr3:97,968,084–97,968,252 | 4.2 kb | Proximal (<10kb) | 35 | |
| chr3:97,971,537–97,972,753 | 226 bp | At TSS Multiome | 729 | |
| chr3:97,979,714–97,980,125 | 7.3 kb | Proximal (<10kb) | 151 |
Genomic view of the RIOX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.