The protein encoded by this gene competes with pICln for inclusion in the protein arginine methyltransferase 5 complex. This complex targets substrates for dimethylation. The encoded protein is essential for the last steps in the maturation of 40S subunits. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for RIOK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIOK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIOK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:7,106,611–7,109,813 | 282.1 kb | Distal (>10kb) Multiome | 938 | |
| chr6:7,140,630–7,141,553 | 248.7 kb | Distal (>10kb) Multiome | 863 | |
| chr6:7,173,710–7,174,435 | 215.9 kb | Distal (>10kb) Multiome | 276 | |
| chr6:7,183,372–7,184,225 | 206.0 kb | Distal (>10kb) Multiome | 129 | |
| chr6:7,260,713–7,262,501 | 128.4 kb | Distal (>10kb) Multiome | 852 | |
| chr6:7,312,560–7,313,754 | 76.6 kb | Distal (>10kb) Multiome | 1075 | |
| chr6:7,347,359–7,348,352 | 42.0 kb | Distal (>10kb) Multiome | 256 | |
| chr6:7,389,283–7,390,343 | 5 bp | At TSS Multiome | 1040 | |
| chr6:7,541,127–7,543,319 | 151.7 kb | Distal (>10kb) Multiome | 970 | |
| chr6:7,548,319–7,549,268 | 158.9 kb | Distal (>10kb) Multiome | 504 | |
| chr6:7,589,842–7,590,956 | 200.4 kb | Distal (>10kb) Multiome | 877 | |
| chr6:7,615,396–7,616,491 | 226.2 kb | Distal (>10kb) Multiome | 297 | |
| chr6:7,672,770–7,673,478 | 283.4 kb | Distal (>10kb) Multiome | 337 |
Genomic view of the RIOK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.