Summary: This protein encoded by this gene is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases. The protein functions as a guanine nucleotide exchange for RAB5B and RAB31. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for RIN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:92,322,882–92,323,968 | 190.3 kb | Distal (>10kb) Multiome | 231 | |
| chr14:92,513,360–92,514,870 | 17 bp | At TSS Multiome | 653 | |
| chr14:92,686,749–92,687,662 | 173.3 kb | Distal (>10kb) Multiome | 399 | |
| chr14:92,747,966–92,748,906 | 234.9 kb | Distal (>10kb) Multiome | 755 | |
| chr14:92,793,733–92,794,894 | 280.4 kb | Distal (>10kb) Multiome | 863 |
Genomic view of the RIN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.