Enables G-protein alpha-subunit binding activity. Acts upstream of or within regulation of G protein-coupled receptor signaling pathway. Located in centrosome; cytosol; and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RIC8B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RIC8B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RIC8B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:106,581,330–106,582,388 | 192.9 kb | Distal (>10kb) Multiome | 219 | |
| chr12:106,582,587–106,584,555 | 191.6 kb | Distal (>10kb) Multiome | 216 | |
| chr12:106,585,673–106,587,837 | 187.3 kb | Distal (>10kb) Multiome | 248 | |
| chr12:106,768,052–106,768,482 | 6.1 kb | Proximal (<10kb) | 190 | |
| chr12:106,773,771–106,775,183 | 227 bp | At TSS Multiome | 953 | |
| chr12:106,903,307–106,903,916 | 129.1 kb | Distal (>10kb) Multiome | 193 | |
| chr12:106,954,854–106,956,979 | 181.1 kb | Distal (>10kb) Multiome | 927 | |
| chr12:106,986,640–106,987,674 | 212.6 kb | Distal (>10kb) Multiome | 764 |
Genomic view of the RIC8B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.