This gene encodes a member of the rhophilin family of Ras-homologous (Rho)-GTPase binding proteins. The encoded protein binds both GTP- and GDP-bound RhoA and GTP-bound RhoB and may be involved in the organization of the actin cytoskeleton. [provided by RefSeq, Apr 2009]
Transcription factors with Perturb-seq knockdown data for RHPN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHPN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHPN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:32,971,721–32,972,560 | 92.8 kb | Distal (>10kb) Multiome | 796 | |
| chr19:33,022,514–33,023,071 | 42.1 kb | Distal (>10kb) Multiome | 102 | |
| chr19:33,032,077–33,032,955 | 32.4 kb | Distal (>10kb) Multiome | 217 | |
| chr19:33,055,839–33,056,064 | 8.8 kb | Proximal (<10kb) | 71 | |
| chr19:33,064,252–33,065,504 | 11 bp | At TSS Multiome | 603 | |
| chr19:33,080,776–33,081,465 | 16.2 kb | Distal (>10kb) Multiome | 838 | |
| chr19:33,124,582–33,125,060 | 60.0 kb | Distal (>10kb) Multiome | 321 | |
| chr19:33,176,278–33,177,966 | 112.3 kb | Distal (>10kb) Multiome | 1077 | |
| chr19:33,193,912–33,194,503 | 129.4 kb | Distal (>10kb) Multiome | 256 | |
| chr19:33,225,334–33,226,211 | 160.8 kb | Distal (>10kb) Multiome | 146 | |
| chr19:33,226,520–33,227,396 | 162.2 kb | Distal (>10kb) Multiome | 219 | |
| chr19:33,301,181–33,303,965 | 237.8 kb | Distal (>10kb) Multiome | 945 |
Genomic view of the RHPN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.