This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RHOC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHOC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHOC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:112,390,678–112,391,531 | 316.1 kb | Distal (>10kb) Multiome HiCAR | 470 | |
| chr1:112,395,753–112,396,890 | 311.0 kb | Distal (>10kb) Multiome HiCAR | 600 | |
| chr1:112,465,931–112,466,532 | 240.9 kb | Distal (>10kb) Multiome | 686 | |
| chr1:112,501,804–112,502,551 | 205.0 kb | Distal (>10kb) Multiome | 420 | |
| chr1:112,507,925–112,508,314 | 199.1 kb | Distal (>10kb) Multiome HiCAR | 122 | |
| chr1:112,508,429–112,509,558 | 198.2 kb | Distal (>10kb) Multiome | 413 | |
| chr1:112,524,298–112,524,779 | 182.7 kb | Distal (>10kb) Multiome | 127 | |
| chr1:112,618,652–112,620,129 | 87.4 kb | Distal (>10kb) Multiome | 956 | |
| chr1:112,674,125–112,675,737 | 31.8 kb | Distal (>10kb) Multiome | 910 | |
| chr1:112,698,555–112,699,277 | 7.9 kb | Proximal (<10kb) | 381 | |
| chr1:112,700,203–112,701,476 | 6.3 kb | Proximal (<10kb) Multiome | 765 | |
| chr1:112,704,514–112,705,591 | 2.0 kb | Proximal (<10kb) Multiome | 694 | |
| chr1:112,706,536–112,707,966 | 136 bp | At TSS Multiome | 784 | |
| chr1:112,714,149–112,716,774 | 9.5 kb | Proximal (<10kb) Multiome | 765 | |
| chr1:112,743,679–112,744,585 | 37.0 kb | Distal (>10kb) Multiome | 198 | |
| chr1:112,790,881–112,791,569 | 84.2 kb | Distal (>10kb) Multiome | 158 | |
| chr1:112,794,180–112,795,498 | 87.9 kb | Distal (>10kb) Multiome | 251 | |
| chr1:112,809,091–112,810,187 | 102.5 kb | Distal (>10kb) Multiome | 445 | |
| chr1:112,817,716–112,818,473 | 111.0 kb | Distal (>10kb) Multiome | 249 | |
| chr1:112,819,120–112,820,730 | 112.3 kb | Distal (>10kb) Multiome | 456 | |
| chr1:112,825,474–112,826,954 | 118.8 kb | Distal (>10kb) Multiome | 182 | |
| chr1:112,841,024–112,841,798 | 134.2 kb | Distal (>10kb) Multiome | 215 | |
| chr1:112,849,324–112,850,157 | 142.6 kb | Distal (>10kb) Multiome | 352 | |
| chr1:112,955,281–112,957,849 | 249.2 kb | Distal (>10kb) Multiome | 1108 |
Genomic view of the RHOC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.