This gene is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and cell cycle progression due to its role in the insulin/TOR/S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RHEB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHEB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHEB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:151,172,589–151,173,067 | 347.1 kb | Distal (>10kb) Multiome | 592 | |
| chr7:151,226,743–151,227,948 | 292.5 kb | Distal (>10kb) Multiome | 820 | |
| chr7:151,232,039–151,233,087 | 287.4 kb | Distal (>10kb) Multiome | 692 | |
| chr7:151,244,849–151,245,940 | 274.3 kb | Distal (>10kb) Multiome | 325 | |
| chr7:151,247,809–151,249,951 | 271.1 kb | Distal (>10kb) Multiome | 522 | |
| chr7:151,251,506–151,252,414 | 268.0 kb | Distal (>10kb) Multiome | 448 | |
| chr7:151,259,810–151,260,360 | 259.8 kb | Distal (>10kb) Multiome | 135 | |
| chr7:151,275,718–151,276,602 | 243.6 kb | Distal (>10kb) Multiome | 99 | |
| chr7:151,276,919–151,277,487 | 242.7 kb | Distal (>10kb) Multiome | 367 | |
| chr7:151,303,363–151,304,005 | 216.3 kb | Distal (>10kb) Multiome | 458 | |
| chr7:151,306,906–151,307,424 | 212.8 kb | Distal (>10kb) Multiome | 60 | |
| chr7:151,341,187–151,342,118 | 178.2 kb | Distal (>10kb) Multiome | 757 | |
| chr7:151,408,879–151,410,989 | 109.8 kb | Distal (>10kb) Multiome | 407 | |
| chr7:151,439,682–151,441,031 | 79.8 kb | Distal (>10kb) Multiome | 189 | |
| chr7:151,448,171–151,448,932 | 71.2 kb | Distal (>10kb) Multiome | 403 | |
| chr7:151,471,779–151,472,110 | at TSS | At TSS | 133 | |
| chr7:151,472,215–151,472,496 | 148 bp | At TSS | 113 | |
| chr7:151,519,052–151,521,056 | 208 bp | At TSS Multiome | 899 | |
| chr7:151,631,518–151,633,118 | 112.4 kb | Distal (>10kb) Multiome | 611 | |
| chr7:151,705,224–151,705,878 | 185.7 kb | Distal (>10kb) Multiome | 192 | |
| chr7:151,782,698–151,783,271 | 263.2 kb | Distal (>10kb) Multiome | 498 |
Genomic view of the RHEB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.