Predicted to enable serine-type endopeptidase activity. Predicted to act upstream of or within several processes, including MAPK cascade; negative regulation of natural killer cell activation; and positive regulation of protein catabolic process. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RHBDD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RHBDD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RHBDD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:29,004,535–29,005,249 | 263.3 kb | Distal (>10kb) Multiome | 417 | |
| chr22:29,029,712–29,031,115 | 237.3 kb | Distal (>10kb) Multiome | 773 | |
| chr22:29,071,484–29,071,874 | 196.7 kb | Distal (>10kb) Multiome | 332 | |
| chr22:29,072,494–29,074,480 | 195.3 kb | Distal (>10kb) Multiome | 537 | |
| chr22:29,205,602–29,206,473 | 62.2 kb | Distal (>10kb) Multiome | 378 | |
| chr22:29,267,574–29,268,917 | 71 bp | At TSS Multiome | 969 | |
| chr22:29,304,664–29,307,808 | 38.7 kb | Distal (>10kb) Multiome | 839 | |
| chr22:29,313,065–29,313,784 | 45.1 kb | Distal (>10kb) Multiome | 274 | |
| chr22:29,315,074–29,316,064 | 47.4 kb | Distal (>10kb) Multiome | 242 | |
| chr22:29,388,161–29,388,971 | 120.4 kb | Distal (>10kb) Multiome | 740 | |
| chr22:29,431,916–29,432,715 | 164.1 kb | Distal (>10kb) Multiome | 14 | |
| chr22:29,470,132–29,470,844 | 202.2 kb | Distal (>10kb) Multiome | 437 | |
| chr22:29,480,003–29,481,437 | 212.8 kb | Distal (>10kb) Multiome | 384 | |
| chr22:29,553,345–29,553,988 | 285.5 kb | Distal (>10kb) Multiome | 837 |
Genomic view of the RHBDD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.