RGS19

regulator of G protein signaling 19 | GAIP, RGSGAIP

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Member of: DE-1

Biological processes 13 terms

G protein-coupled receptor signaling pathway (GO:0007186)GTPase activator activity (GO:0005096)GTPase activity (GO:0003924)GTPase activity (GO:0003924)Golgi apparatus (GO:0005794)cell junction (GO:0030054)cytoplasmic side of plasma membrane (GO:0009898)membrane (GO:0016020)membrane (GO:0016020)negative regulation of G protein-coupled receptor signaling pathway (GO:0045744)plasma membrane (GO:0005886)protein binding (GO:0005515)small GTPase-mediated signal transduction (GO:0007264)

Expression (TPM)

TFs regulating RGS19 0 TFs

Transcription factors with Perturb-seq knockdown data for RGS19. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RGS19 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RGS19

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RGS19, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr20:63,830,341–63,832,721	248.5 kb	Distal (>10kb) Multiome	628
chr20:63,846,273–63,846,790	233.3 kb	Distal (>10kb) Multiome	487
chr20:63,864,234–63,865,991	214.7 kb	Distal (>10kb) Multiome	1158
chr20:63,894,341–63,895,764	184.8 kb	Distal (>10kb) Multiome	791
chr20:63,938,191–63,939,815	141.1 kb	Distal (>10kb) Multiome	287
chr20:63,939,918–63,942,008	138.2 kb	Distal (>10kb) Multiome	496
chr20:63,955,375–63,956,875	123.4 kb	Distal (>10kb) Multiome	1107
chr20:63,956,976–63,958,127	122.2 kb	Distal (>10kb) Multiome	709
chr20:63,969,149–63,970,667	109.9 kb	Distal (>10kb) Multiome	764
chr20:63,973,660–63,974,150	105.9 kb	Distal (>10kb) Multiome	767
chr20:63,980,541–63,981,488	98.7 kb	Distal (>10kb) Multiome	986
chr20:64,030,226–64,031,221	49.1 kb	Distal (>10kb) Multiome	159
chr20:64,038,338–64,039,469	40.7 kb	Distal (>10kb) Multiome	628
chr20:64,047,989–64,049,987	30.3 kb	Distal (>10kb) Multiome	541
chr20:64,053,902–64,054,682	25.5 kb	Distal (>10kb) Multiome	609
chr20:64,057,481–64,058,099	21.9 kb	Distal (>10kb) Multiome	659
chr20:64,062,561–64,063,881	16.7 kb	Distal (>10kb) Multiome	991
chr20:64,079,311–64,080,472	119 bp	At TSS Multiome	688
chr20:64,083,392–64,084,408	3.9 kb	Proximal (<10kb) Multiome	591
chr20:64,084,653–64,085,015	4.7 kb	Proximal (<10kb)	113
chr20:64,101,897–64,102,924	22.5 kb	Distal (>10kb) Multiome	457
chr20:64,160,199–64,160,889	80.7 kb	Distal (>10kb) Multiome	55
chr20:64,255,171–64,256,183	175.8 kb	Distal (>10kb) Multiome	861

Genome Browser

Genomic view of the RGS19 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.