Predicted to enable small GTPase binding activity. Predicted to contribute to GTPase activator activity. Predicted to be involved in NLS-bearing protein import into nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RGPD8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RGPD8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RGPD8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:111,883,652–111,884,536 | 549.5 kb | Distal (>10kb) Multiome HiCAR | 911 | |
| chr2:112,053,884–112,054,856 | 379.2 kb | Distal (>10kb) Multiome HiCAR | 492 | |
| chr2:112,054,956–112,056,432 | 378.4 kb | Distal (>10kb) Multiome HiCAR | 968 | |
| chr2:112,181,502–112,182,275 | 251.8 kb | Distal (>10kb) Multiome | 174 | |
| chr2:112,254,532–112,255,517 | 178.6 kb | Distal (>10kb) Multiome HiCAR | 915 | |
| chr2:112,275,156–112,276,567 | 157.4 kb | Distal (>10kb) Multiome HiCAR | 1201 | |
| chr2:112,480,926–112,482,608 | 47.5 kb | Distal (>10kb) Multiome | 860 | |
| chr2:112,541,785–112,542,849 | 108.6 kb | Distal (>10kb) Multiome | 1070 | |
| chr2:112,583,940–112,585,172 | 150.9 kb | Distal (>10kb) Multiome | 949 | |
| chr2:112,645,080–112,646,681 | 212.2 kb | Distal (>10kb) Multiome | 980 | |
| chr2:112,674,793–112,675,390 | 241.4 kb | Distal (>10kb) Multiome | 54 | |
| chr2:112,726,233–112,727,218 | 293.2 kb | Distal (>10kb) Multiome | 667 |
Genomic view of the RGPD8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.