Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in cytosol. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RGL3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RGL3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RGL3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:11,137,551–11,138,233 | 281.4 kb | Distal (>10kb) Multiome | 584 | |
| chr19:11,155,520–11,156,298 | 263.4 kb | Distal (>10kb) Multiome | 754 | |
| chr19:11,196,759–11,198,184 | 221.6 kb | Distal (>10kb) Multiome | 728 | |
| chr19:11,243,345–11,243,968 | 175.8 kb | Distal (>10kb) Multiome | 448 | |
| chr19:11,262,060–11,262,653 | 156.9 kb | Distal (>10kb) Multiome | 406 | |
| chr19:11,339,100–11,339,837 | 79.7 kb | Distal (>10kb) Multiome | 506 | |
| chr19:11,346,053–11,346,958 | 72.8 kb | Distal (>10kb) Multiome | 676 | |
| chr19:11,355,078–11,355,735 | 63.9 kb | Distal (>10kb) Multiome | 382 | |
| chr19:11,361,368–11,362,625 | 57.7 kb | Distal (>10kb) Multiome | 256 | |
| chr19:11,374,474–11,375,717 | 44.4 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,380,761–11,382,262 | 38.0 kb | Distal (>10kb) Multiome | 798 | |
| chr19:11,382,830–11,384,509 | 35.0 kb | Distal (>10kb) Multiome | 761 | |
| chr19:11,418,061–11,419,498 | 699 bp | At TSS Multiome | 421 | |
| chr19:11,420,614–11,422,979 | 2.8 kb | Proximal (<10kb) Multiome | 507 | |
| chr19:11,434,817–11,436,365 | 16.0 kb | Distal (>10kb) Multiome | 927 | |
| chr19:11,479,217–11,480,146 | 60.3 kb | Distal (>10kb) Multiome | 394 | |
| chr19:11,481,847–11,483,040 | 63.4 kb | Distal (>10kb) Multiome | 938 | |
| chr19:11,504,741–11,506,612 | 86.0 kb | Distal (>10kb) Multiome | 854 | |
| chr19:11,528,581–11,529,391 | 109.8 kb | Distal (>10kb) Multiome | 866 | |
| chr19:11,535,847–11,536,353 | 116.9 kb | Distal (>10kb) Multiome | 694 | |
| chr19:11,538,464–11,539,111 | 119.4 kb | Distal (>10kb) Multiome | 235 | |
| chr19:11,539,738–11,540,434 | 120.7 kb | Distal (>10kb) Multiome | 176 | |
| chr19:11,558,908–11,559,777 | 140.0 kb | Distal (>10kb) Multiome | 686 | |
| chr19:11,597,206–11,598,107 | 178.1 kb | Distal (>10kb) Multiome | 914 | |
| chr19:11,639,337–11,640,481 | 220.4 kb | Distal (>10kb) Multiome | 660 | |
| chr19:11,694,497–11,695,341 | 275.7 kb | Distal (>10kb) Multiome | 608 |
Genomic view of the RGL3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.