This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]
Transcription factors with Perturb-seq knockdown data for REXO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = REXO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of REXO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:114,219,750–114,220,331 | 219.3 kb | Distal (>10kb) Multiome | 188 | |
| chr11:114,232,562–114,233,037 | 206.6 kb | Distal (>10kb) Multiome | 66 | |
| chr11:114,280,655–114,281,133 | 158.6 kb | Distal (>10kb) Multiome | 266 | |
| chr11:114,399,639–114,401,087 | 38.9 kb | Distal (>10kb) Multiome | 1001 | |
| chr11:114,438,297–114,438,739 | 694 bp | At TSS | 55 | |
| chr11:114,439,222–114,440,261 | 72 bp | At TSS Multiome | 796 | |
| chr11:114,559,427–114,560,368 | 120.4 kb | Distal (>10kb) Multiome | 99 |
Genomic view of the REXO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.