Predicted to act upstream of or within chromatin organization; neuron differentiation; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RENO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RENO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RENO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:81,101,596–81,102,059 | 244.1 kb | Distal (>10kb) Multiome | 815 | |
| chr17:81,222,360–81,223,690 | 122.8 kb | Distal (>10kb) Multiome | 861 | |
| chr17:81,238,602–81,239,760 | 106.8 kb | Distal (>10kb) Multiome | 811 | |
| chr17:81,295,024–81,295,658 | 50.7 kb | Distal (>10kb) Multiome | 832 | |
| chr17:81,339,311–81,340,470 | 6.5 kb | Proximal (<10kb) Multiome | 474 | |
| chr17:81,342,689–81,343,259 | 2.7 kb | Proximal (<10kb) | 382 | |
| chr17:81,345,409–81,347,165 | 270 bp | At TSS Multiome | 891 | |
| chr17:81,393,141–81,395,575 | 48.1 kb | Distal (>10kb) Multiome | 1168 | |
| chr17:81,396,480–81,397,832 | 51.4 kb | Distal (>10kb) Multiome | 646 | |
| chr17:81,481,258–81,481,865 | 135.6 kb | Distal (>10kb) Multiome | 348 | |
| chr17:81,483,927–81,484,829 | 138.5 kb | Distal (>10kb) Multiome | 828 | |
| chr17:81,487,690–81,488,371 | 142.0 kb | Distal (>10kb) Multiome | 721 | |
| chr17:81,511,887–81,515,656 | 167.0 kb | Distal (>10kb) Multiome | 1116 | |
| chr17:81,518,632–81,519,878 | 173.6 kb | Distal (>10kb) Multiome | 617 | |
| chr17:81,537,462–81,537,907 | 191.7 kb | Distal (>10kb) Multiome | 282 | |
| chr17:81,551,821–81,553,314 | 207.2 kb | Distal (>10kb) Multiome | 845 | |
| chr17:81,636,404–81,637,301 | 291.1 kb | Distal (>10kb) Multiome | 946 |
Genomic view of the RENO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.