The protein encoded by this gene may be involved in the transport of receptors from the endoplasmic reticulum (ER) to the cell surface. The encoded protein may also play a role in regulating ER membrane structure. This gene is required for the proper development of retinal rods and photoreceptors, with defects in this gene being associated with retinitis pigmentosa 77. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for REEP6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = REEP6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of REEP6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:1,205,175–1,206,374 | 285.6 kb | Distal (>10kb) Multiome | 746 | |
| chr19:1,239,513–1,242,539 | 250.9 kb | Distal (>10kb) Multiome | 889 | |
| chr19:1,247,981–1,252,501 | 242.6 kb | Distal (>10kb) Multiome | 1136 | |
| chr19:1,259,185–1,262,955 | 230.2 kb | Distal (>10kb) Multiome | 1070 | |
| chr19:1,265,280–1,270,235 | 221.9 kb | Distal (>10kb) Multiome | 1171 | |
| chr19:1,274,423–1,276,502 | 215.4 kb | Distal (>10kb) Multiome | 967 | |
| chr19:1,285,317–1,286,108 | 205.4 kb | Distal (>10kb) Multiome | 277 | |
| chr19:1,354,303–1,355,411 | 136.3 kb | Distal (>10kb) Multiome | 688 | |
| chr19:1,383,122–1,384,333 | 107.6 kb | Distal (>10kb) Multiome | 1228 | |
| chr19:1,406,589–1,408,783 | 83.7 kb | Distal (>10kb) Multiome | 911 | |
| chr19:1,415,008–1,415,721 | 75.7 kb | Distal (>10kb) Multiome | 597 | |
| chr19:1,437,988–1,438,998 | 52.8 kb | Distal (>10kb) Multiome | 1076 | |
| chr19:1,444,785–1,447,383 | 46.0 kb | Distal (>10kb) Multiome | 797 | |
| chr19:1,455,191–1,456,421 | 35.4 kb | Distal (>10kb) Multiome | 491 | |
| chr19:1,468,941–1,469,903 | 21.9 kb | Distal (>10kb) Multiome | 242 | |
| chr19:1,470,088–1,471,597 | 20.3 kb | Distal (>10kb) Multiome | 544 | |
| chr19:1,478,772–1,479,848 | 11.9 kb | Distal (>10kb) Multiome | 857 | |
| chr19:1,489,566–1,491,829 | 294 bp | At TSS Multiome | 836 | |
| chr19:1,507,230–1,508,699 | 17.0 kb | Distal (>10kb) Multiome | 596 | |
| chr19:1,566,277–1,568,916 | 77.3 kb | Distal (>10kb) Multiome | 748 | |
| chr19:1,592,085–1,593,444 | 101.6 kb | Distal (>10kb) Multiome | 883 | |
| chr19:1,604,859–1,606,501 | 114.5 kb | Distal (>10kb) Multiome | 902 | |
| chr19:1,651,519–1,653,514 | 161.8 kb | Distal (>10kb) Multiome | 909 | |
| chr19:1,725,307–1,726,101 | 234.6 kb | Distal (>10kb) Multiome | 455 |
Genomic view of the REEP6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.