Predicted to enable microtubule binding activity. Involved in mitotic nuclear membrane reassembly. Predicted to be located in endoplasmic reticulum; membrane; and microtubule. Predicted to be active in cytoplasmic microtubule; endoplasmic reticulum membrane; and endoplasmic reticulum tubular network. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for REEP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = REEP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of REEP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:63,268,784–63,269,452 | 252.3 kb | Distal (>10kb) Multiome | 834 | |
| chr10:63,347,833–63,349,212 | 172.8 kb | Distal (>10kb) Multiome | 254 | |
| chr10:63,464,884–63,466,465 | 55.4 kb | Distal (>10kb) Multiome | 987 | |
| chr10:63,475,498–63,476,184 | 45.6 kb | Distal (>10kb) Multiome | 164 | |
| chr10:63,515,009–63,515,274 | 6.1 kb | Proximal (<10kb) | 130 | |
| chr10:63,520,698–63,522,345 | 40 bp | At TSS Multiome | 966 | |
| chr10:63,523,236–63,523,761 | 1.8 kb | Proximal (<10kb) | 38 | |
| chr10:63,629,052–63,631,108 | 109.1 kb | Distal (>10kb) Multiome | 968 | |
| chr10:63,713,131–63,714,105 | 192.1 kb | Distal (>10kb) Multiome | 440 |
Genomic view of the REEP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.