Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for RDX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RDX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RDX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:110,091,940–110,094,243 | 203.7 kb | Distal (>10kb) Multiome | 843 | |
| chr11:110,128,005–110,128,732 | 168.3 kb | Distal (>10kb) Multiome | 206 | |
| chr11:110,173,762–110,174,831 | 122.5 kb | Distal (>10kb) Multiome | 343 | |
| chr11:110,295,762–110,297,308 | 87 bp | At TSS Multiome | 774 | |
| chr11:110,297,422–110,297,603 | 918 bp | At TSS | 105 | |
| chr11:110,297,719–110,298,905 | 1.2 kb | Proximal (<10kb) | 294 | |
| chr11:110,299,121–110,299,380 | 2.6 kb | Proximal (<10kb) | 34 | |
| chr11:110,300,581–110,301,489 | 4.1 kb | Proximal (<10kb) | 76 | |
| chr11:110,337,351–110,338,083 | 41.2 kb | Distal (>10kb) Multiome | 209 | |
| chr11:110,429,644–110,430,937 | 133.4 kb | Distal (>10kb) Multiome | 804 | |
| chr11:110,564,328–110,566,260 | 268.7 kb | Distal (>10kb) Multiome | 299 | |
| chr11:111,976,357–111,978,029 | 1680.6 kb | Distal (>10kb) Multiome HiCAR | 293 |
Genomic view of the RDX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.