Enables all-trans-retinol dehydrogenase (NADP+) activity. Involved in osteoblast differentiation. Located in cytosol; endoplasmic reticulum; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RDH14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RDH14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RDH14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:18,387,079–18,388,234 | 172.9 kb | Distal (>10kb) Multiome | 366 | |
| chr2:18,400,765–18,402,339 | 159.0 kb | Distal (>10kb) Multiome | 133 | |
| chr2:18,546,509–18,546,987 | 13.9 kb | Distal (>10kb) Multiome | 197 | |
| chr2:18,559,599–18,561,088 | 75 bp | At TSS Multiome | 962 | |
| chr2:18,568,623–18,569,011 | 8.0 kb | Proximal (<10kb) | 9 | |
| chr2:18,777,226–18,778,062 | 216.9 kb | Distal (>10kb) Multiome | 358 | |
| chr2:18,836,102–18,837,761 | 276.0 kb | Distal (>10kb) Multiome | 215 | |
| chr2:19,347,544–19,348,931 | 787.5 kb | Distal (>10kb) Multiome HiCAR | 939 | |
| chr2:19,349,658–19,351,441 | 789.7 kb | Distal (>10kb) Multiome HiCAR | 369 | |
| chr2:19,863,073–19,864,223 | 1302.9 kb | Distal (>10kb) Multiome HiCAR | 720 | |
| chr2:19,868,540–19,869,572 | 1308.2 kb | Distal (>10kb) Multiome HiCAR | 302 |
Genomic view of the RDH14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.