RDH13

retinol dehydrogenase 13 | SDR7C3

This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Developmental clusters: GC1

Biological processes 15 terms

all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650)all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650)all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650)all-trans-retinol dehydrogenase (NADP+) activity (GO:0052650)eye photoreceptor cell development (GO:0042462)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrion (GO:0005739)mitochondrion (GO:0005739)retina layer formation (GO:0010842)retinal metabolic process (GO:0042574)retinal metabolic process (GO:0042574)retinol metabolic process (GO:0042572)

Expression (TPM)

TFs regulating RDH13 0 TFs

Transcription factors with Perturb-seq knockdown data for RDH13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RDH13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RDH13

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RDH13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:54,462,469–54,465,494	599.1 kb	Distal (>10kb) Multiome HiCAR	1004
chr19:55,062,536–55,063,406	55 bp	At TSS Multiome	586
chr19:55,069,129–55,069,807	6.3 kb	Proximal (<10kb) Multiome	288
chr19:55,080,038–55,082,744	18.4 kb	Distal (>10kb) Multiome	639
chr19:55,086,246–55,087,525	24.0 kb	Distal (>10kb) Multiome	258
chr19:55,091,780–55,093,292	29.2 kb	Distal (>10kb) Multiome	208
chr19:55,095,398–55,095,977	32.7 kb	Distal (>10kb) Multiome	90
chr19:55,117,134–55,119,109	54.6 kb	Distal (>10kb) Multiome	881
chr19:55,146,210–55,148,117	83.8 kb	Distal (>10kb) Multiome	528
chr19:55,156,193–55,157,266	93.5 kb	Distal (>10kb) Multiome	317
chr19:55,160,567–55,161,360	97.6 kb	Distal (>10kb) Multiome	554
chr19:55,165,952–55,167,256	103.6 kb	Distal (>10kb) Multiome	719
chr19:55,173,717–55,174,287	111.0 kb	Distal (>10kb) Multiome	330
chr19:55,178,876–55,179,477	116.0 kb	Distal (>10kb) Multiome	479
chr19:55,216,490–55,217,227	153.8 kb	Distal (>10kb) Multiome	1077
chr19:55,257,751–55,259,635	196.1 kb	Distal (>10kb) Multiome	1054
chr19:55,279,599–55,280,933	217.2 kb	Distal (>10kb) Multiome	805
chr19:55,283,835–55,284,716	220.9 kb	Distal (>10kb) Multiome	242
chr19:55,301,640–55,302,240	238.8 kb	Distal (>10kb) Multiome	448
chr19:55,338,676–55,340,358	276.5 kb	Distal (>10kb) Multiome	882
chr19:55,340,675–55,341,535	278.3 kb	Distal (>10kb) Multiome	368
chr19:55,353,720–55,354,487	291.0 kb	Distal (>10kb) Multiome	297

Genome Browser

Genomic view of the RDH13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.