Predicted to enable enzyme binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RCOR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RCOR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RCOR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:209,427,749–209,429,011 | 1830.9 kb | Distal (>10kb) Multiome HiCAR | 272 | |
| chr1:211,133,108–211,134,829 | 125.1 kb | Distal (>10kb) Multiome HiCAR | 739 | |
| chr1:211,222,016–211,223,252 | 36.7 kb | Distal (>10kb) Multiome | 343 | |
| chr1:211,257,043–211,257,661 | 1.7 kb | Proximal (<10kb) | 104 | |
| chr1:211,258,333–211,261,113 | 97 bp | At TSS Multiome | 1149 | |
| chr1:211,326,284–211,327,905 | 67.5 kb | Distal (>10kb) Multiome | 543 | |
| chr1:211,375,133–211,375,818 | 116.1 kb | Distal (>10kb) Multiome | 107 | |
| chr1:211,382,531–211,383,307 | 123.4 kb | Distal (>10kb) Multiome | 921 | |
| chr1:211,398,188–211,399,458 | 139.4 kb | Distal (>10kb) Multiome | 128 | |
| chr1:211,399,597–211,400,219 | 140.8 kb | Distal (>10kb) Multiome | 80 | |
| chr1:211,416,272–211,417,162 | 157.3 kb | Distal (>10kb) Multiome | 257 | |
| chr1:211,469,768–211,470,490 | 210.8 kb | Distal (>10kb) Multiome | 383 | |
| chr1:211,513,158–211,514,512 | 254.8 kb | Distal (>10kb) Multiome | 484 | |
| chr1:211,515,159–211,516,023 | 256.2 kb | Distal (>10kb) Multiome | 818 |
Genomic view of the RCOR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.