The protein encoded by this gene is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. This gene maps to the same region as type 4 Bardet-Biedl syndrome, suggesting a possible causative role for this gene in the disorder. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]
Transcription factors with Perturb-seq knockdown data for RCN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RCN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RCN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:76,904,474–76,906,082 | 26.3 kb | Distal (>10kb) Multiome | 1003 | |
| chr15:76,931,243–76,932,242 | 66 bp | At TSS Multiome | 693 | |
| chr15:76,973,226–76,973,843 | 41.8 kb | Distal (>10kb) Multiome | 182 | |
| chr15:77,027,800–77,028,685 | 96.6 kb | Distal (>10kb) Multiome | 156 | |
| chr15:77,070,415–77,071,533 | 139.4 kb | Distal (>10kb) Multiome | 652 |
Genomic view of the RCN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.