This gene encodes a protein containing two C-terminal BTB/POZ domains that is related to regulator of chromosome condensation (RCC). The encoded protein may act as a guanine nucleotide exchange factor. This gene is observed to be lost or underexpressed in prostate cancers. There is a pseudogene of this gene on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
Transcription factors with Perturb-seq knockdown data for RCBTB2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RCBTB2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RCBTB2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:48,232,588–48,234,160 | 300.0 kb | Distal (>10kb) Multiome | 750 | |
| chr13:48,303,216–48,304,354 | 229.5 kb | Distal (>10kb) Multiome | 827 | |
| chr13:48,531,782–48,533,660 | 377 bp | At TSS Multiome | 884 | |
| chr13:48,533,833–48,534,534 | 753 bp | At TSS | 99 | |
| chr13:48,542,596–48,543,062 | 9.5 kb | Proximal (<10kb) | 180 | |
| chr13:48,621,052–48,621,542 | 88.0 kb | Distal (>10kb) Multiome | 149 | |
| chr13:48,645,781–48,646,616 | 112.9 kb | Distal (>10kb) Multiome | 67 |
Genomic view of the RCBTB2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.